FAB-BASED INHIBITORS REVEAL UBIQUITIN INDEPENDENT FUNCTIONS FOR HIV VIF NEUTRALIZATION OF APOBEC3 RESTRICTION FACTORS.

Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.

The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection.Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by recruiting them to a multi-protein ubiquitin E3 ligase complex.Here, we describe longbow a degradation-

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Hard Machining of Spur Gears with the InvoMillingTM Method

Recently, the 5-axis machining of gears has become increasingly important.This technology enables a flexible production of diverse gear types on a single universal machine with standard tools.In addition to the economic aspects, the focus is on the high quality standards that has to be Bike Racks achieved.This paper deals with hard machining for th

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